Temporal trends in artemisinin partial resistance and other antimalarial drug mutations in Plasmodium falciparum from Kagera region, Northwestern Tanzania, 2021–2023
Alfred Simkin, Salehe S. Mandai, Abebe A. Fola, Neeva Wernsman Young, Jacob Marglous, Dativa Pereus, Catherine Bakari, Rashid A. Madebe, Misago D. Seth, Rule B. Mrengela, Angelina J. Kisambale, Gervas A. Chacha, Celine I. Mandara, Filbert Francis, Daniel Mbwambo, Issa Garimo, Frank Chacky, Sijenunu · 2026
Read Temporal trends in artemisinin partial resistance and other antimalarial drug mutations in Plasmodium falciparum from Kagera region, Northwestern Tanzania, 2021–2023 by Alfred Simkin, Salehe S. Mandai, Abebe A. Fola, Neeva Wernsman Young, Jacob Marglous, Dativa Pereus, Catherine Bakari, Rashid A. Madebe, Misago D. Seth, Rule B. Mrengela, Angelina J. Kisambale, Gervas A. Chacha, Celine I. Mandara, Filbert Francis, Daniel Mbwambo, Issa Garimo, Frank Chacky, Sijenunu (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13271678.txt.
Description
Alfred Simkin and colleagues track in 2026 how malaria drug resistance markers changed in Tanzania's Kagera region between 2021 and 2023. Artemisinin-based drug pairs remain the main malaria treatment, but partial resistance has emerged in East Africa. One gene change, called R561H, is linked to slower parasite clearing after treatment.
The team genotyped 2,866 parasite samples from seven districts with targeted probes. The R561H change persisted near the border and appeared in new districts, showing eastward spread toward Lake Victoria. Its regional share rose across the study years, while markers tied to partner drugs barely moved. Continued watching is needed to protect treatment success.
Catalog record
| CREATOR | Alfred Simkin, Salehe S. Mandai, Abebe A. Fola, Neeva Wernsman Young, Jacob Marglous, Dativa Pereus, Catherine Bakari, Rashid A. Madebe, Misago D. Seth, Rule B. Mrengela, Angelina J. Kisambale, Gervas A. Chacha, Celine I. Mandara, Filbert Francis, Daniel Mbwambo, Issa Garimo, Frank Chacky, Sijenunu |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 43 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |