Remodeling the marrow fat niche: BMAT in cancer bone metastases and hematological malignancies
Izabela Podgorski · 2026
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Description
Izabela Podgorski reviews in 2026 how fat tissue inside bone marrow helps cancers survive in bone. Marrow fat was once seen as filler, but it actively feeds and shields tumor cells. Cancers that spread to bone, and blood cancers that grow there, both draw on this niche.
Signals passing between tumor cells and fat-forming cells change fat release, stress balance, and tissue repair inside the marrow. Cancer treatment itself can leave behind inflamed or aged niches that shelter leftover tumor cells. At the same time, fat-lineage cells help repair marrow after injury. Sorting helpful repair states from tumor-friendly ones is a central task ahead.
Catalog record
| CREATOR | Izabela Podgorski |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 23 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |