Estrogen impacts NOD2-dependent regulation of intestinal homeostasis
Mckenna Eklund, Edan Foley, Ines Alvarez-Garcia, Ines Alvarez-Garcia, Ines Alvarez-Garcia, Ines Alvarez-Garcia · 2026
Read Estrogen impacts NOD2-dependent regulation of intestinal homeostasis by Mckenna Eklund, Edan Foley, Ines Alvarez-Garcia, Ines Alvarez-Garcia, Ines Alvarez-Garcia, Ines Alvarez-Garcia (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13271492.txt.
Description
Mckenna Eklund and colleagues report in 2026 on a surprising link between the hormone estrogen and gut health in a Crohn's disease model. Changes in the immune sensor NOD2 form the strongest known genetic risk for Crohn's disease. How that sensor keeps the intestine stable has stayed unclear.
Working with zebrafish that lack a working nod2 gene, the team found disturbed gut tissue and raised activity in estrogen-response genes. Estrogen alone copied the defects seen in the mutant fish, while a drug that blocks estrogen signaling repaired them. The results suggest hormone signals may help explain why Crohn's disease can differ between the sexes.
Catalog record
| CREATOR | Mckenna Eklund, Edan Foley, Ines Alvarez-Garcia, Ines Alvarez-Garcia, Ines Alvarez-Garcia, Ines Alvarez-Garcia |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 122 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |