Hypergravity reduces F-actin accumulation in osteoclasts, with attenuated bone resorption
Natsuhiro Takahashi, Akihiko Fujita, Yuki Azetsu, Akiko Karakawa, Mie Myers, Masamichi Takami, Masahiro Chatani · 2026
Read Hypergravity reduces F-actin accumulation in osteoclasts, with attenuated bone resorption by Natsuhiro Takahashi, Akihiko Fujita, Yuki Azetsu, Akiko Karakawa, Mie Myers, Masamichi Takami, Masahiro Chatani (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/PMC13271441.txt.
Description
Natsuhiro Takahashi is lead author of a 2026 journal article on how high gravity affects osteoclasts, the cells that break down bone. Bone loss in astronauts shows the skeleton senses gravity changes, and stronger-than-normal gravity, made with a centrifuge, offers a way to test how bone-eating cells respond to mechanical force.
Mouse bone marrow osteoclasts were exposed to gravity up to thirty times Earth's, for as little as thirty minutes. High gravity damaged the actin rings these cells use to seal onto bone, dimmed their structure, and moved cell nuclei, while other supports stayed unchanged. Resorption pits in dentine shrank in step. Protein tagging analysis showed wide changes across cell structure, signalling, and control pathways.
Catalog record
| CREATOR | Natsuhiro Takahashi, Akihiko Fujita, Yuki Azetsu, Akiko Karakawa, Mie Myers, Masamichi Takami, Masahiro Chatani |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 74039 |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |