Membrane vesicles associated antimicrobial peptides from PGPR Priestia megaterium VIT-2021 confer in silico efficacy against Pseudomonas syringae virulence protein
Huldah Pearlin Sarah Lazarus, Nalini Easwaran · 2026
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Description
Huldah Pearlin Sarah Lazarus and Nalini Easwaran report a 2026 computer-based study of small bacteria-killing proteins. These proteins are carried in membrane vesicles from a plant-helping bacterium, Priestia megaterium. Earlier work showed these vesicles can inhibit Pseudomonas syringae, a plant pathogen. The authors asked whether the proteins could bind its virulence proteins, the tools it uses to attack plants.
Docking simulations, which model how molecules fit together, showed strong binding between the proteins and five pathogen proteins. Longer dynamics simulations confirmed the best fits stayed stable. Because all evidence here is computed, not from live tests, the authors frame the proteins as promising candidates. They build on earlier laboratory findings.
Catalog record
| CREATOR | Huldah Pearlin Sarah Lazarus, Nalini Easwaran |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 31808 |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |