Discovery and optimization of marstacimab, a human monoclonal antibody targeting tissue factor pathway inhibitor for the treatment of hemophilia A and B
Macy Jin, Sunita Hett, Reema Jasuja, Swapnil Rakhe, Jatin Narula, Amy Tam, James R Apgar, Zong Sean Juo, Lidia Mosyak, Matthew Holsti, Alison Joyce, Susan Hurst, Robert Webster, Laura Lin, Mark Stahl, Debra D Pittman, Laird Bloom · 2026
Read Discovery and optimization of marstacimab, a human monoclonal antibody targeting tissue factor pathway inhibitor for the treatment of hemophilia A and B by Macy Jin, Sunita Hett, Reema Jasuja, Swapnil Rakhe, Jatin Narula, Amy Tam, James R Apgar, Zong Sean Juo, Lidia Mosyak, Matthew Holsti, Alison Joyce, Susan Hurst, Robert Webster, Laura Lin, Mark Stahl, Debra D Pittman, Laird Bloom (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/PMC13271316.txt.
Description
Macy Jin is lead author of a 2026 journal article reporting the discovery and tuning of marstacimab. That is a human monoclonal antibody for haemophilia A and B. In those conditions, blood fails to clot properly. The drug blocks TFPI, a natural brake on clotting, freeing a clotting factor to work.
Using two antibody search methods, the team found antibodies that bound TFPI at several spots and stopped it blocking clotting factor Xa. Some cut bleeding in haemophilia mice for up to 96 hours after one dose. Surprisingly, mid-strength binding lasted longest in the blood, while the tightest binders cleared fast. The final candidate, marstacimab, was chosen after checks on stability, thickness, immune risk, and production.
Catalog record
| CREATOR | Macy Jin, Sunita Hett, Reema Jasuja, Swapnil Rakhe, Jatin Narula, Amy Tam, James R Apgar, Zong Sean Juo, Lidia Mosyak, Matthew Holsti, Alison Joyce, Susan Hurst, Robert Webster, Laura Lin, Mark Stahl, Debra D Pittman, Laird Bloom |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 68884 |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |