GLP-1 Receptor Agonists in Neurological Disorders: From Mechanisms to Clinical Translation
Pengpeng Li, Yangyang Gao, Wei Liu · 2026
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Description
Pengpeng Li is lead author of a 2026 review on GLP-1 receptor agonists, drugs long used for type 2 diabetes and obesity, as possible treatments for brain disorders. These receptors are widespread in the central nervous system, raising hopes of reusing the drugs for conditions from Alzheimer's disease to depression.
In animal studies the drugs boosted protective signals, cut harmful protein build-up and neuron loss, and calmed brain inflammation across many disease models. Human trial results are mixed, though, with some showing small gains in thinking or movement and others showing no effect on disease course. The reviewers note the drugs cross into the brain at very different rates, which may explain the uneven results.
Catalog record
| CREATOR | Pengpeng Li, Yangyang Gao, Wei Liu |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 45439 |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |