Determination of the ED50 of Tegileridine and Comparison with Fentanyl for Analgesia During Hysteroscopy in Chinese Female Patients: An Exploratory Sequential Dose‑Finding Study
Houren Xu, Feng Lu, Yu Wang, Xinxin Ruan, Haiyu Xie, Maolin Zhong · 2026
Read Determination of the ED50 of Tegileridine and Comparison with Fentanyl for Analgesia During Hysteroscopy in Chinese Female Patients: An Exploratory Sequential Dose‑Finding Study by Houren Xu, Feng Lu, Yu Wang, Xinxin Ruan, Haiyu Xie, Maolin Zhong (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/PMC13271068.txt.
Description
Houren Xu is lead author of a 2026 dose-finding study of tegileridine, a new pain drug that acts on the mu-opioid receptor, during hysteroscopy, a procedure to look inside the womb. Under propofol anaesthesia, the team sought the dose that suppresses the reflex response to widening the cervix in half of patients, and compared it with fentanyl.
Fifty-four Chinese patients took part, 27 per group, with doses adjusted step by step from the previous patient's result. The half-effective dose was 23.22 micrograms per kilogram for tegileridine and 1.51 for fentanyl, a potency ratio near one to fifteen. Breathing depression or low oxygen appeared in 14.8 percent of the tegileridine group and 59.3 percent of the fentanyl group.
Catalog record
| CREATOR | Houren Xu, Feng Lu, Yu Wang, Xinxin Ruan, Haiyu Xie, Maolin Zhong |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 48320 |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |