Pan-Cancer Analysis of a Depression-Related Gene Signature Identifies an Immunosuppressive Tumor Microenvironment and Links to Immunotherapy Response in Breast Cancer
Guanling Chen, Baoliang Yin, Muhammad Khan, Yipeng Yang, Qian Sun, Tingfeng Zhang, Hong Hu, Jie Lin · 2026
Read Pan-Cancer Analysis of a Depression-Related Gene Signature Identifies an Immunosuppressive Tumor Microenvironment and Links to Immunotherapy Response in Breast Cancer by Guanling Chen, Baoliang Yin, Muhammad Khan, Yipeng Yang, Qian Sun, Tingfeng Zhang, Hong Hu, Jie Lin (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/PMC13271060.txt.
Description
Guanling Chen is lead author of a 2026 pan-cancer analysis, a study across many cancer types, of a depression-related gene signature, a set of 382 genes linked to depression. The team computed a score, called DScore, for over 10,000 tumour samples from 33 cancer types and related it to tumour biology, immune surroundings, and survival.
Higher scores appeared in several gut, brain, kidney, and hormone-related cancers, and linked to older age, later stage, and poorer survival in many cancers, though the survival link reversed in a few. In breast cancer, high scores matched an immune-suppressing tumour setting with fewer killer T cells. One gene, CACNA1H, was checked in breast tissue tests.
Catalog record
| CREATOR | Guanling Chen, Baoliang Yin, Muhammad Khan, Yipeng Yang, Qian Sun, Tingfeng Zhang, Hong Hu, Jie Lin |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 77461 |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |