The “Three-Tier Regulatory Network” of Orthokeratology in Myopia Control: Evidence Weight of Underlying Mechanisms, Controversies, and New Perspectives for Clinical Translation--A Review
Longhui Han, Shangkuan He, Shuting Dong, Yuying Lu, Minglian Zhang · 2026
Read The “Three-Tier Regulatory Network” of Orthokeratology in Myopia Control: Evidence Weight of Underlying Mechanisms, Controversies, and New Perspectives for Clinical Translation--A Review by Longhui Han, Shangkuan He, Shuting Dong, Yuying Lu, Minglian Zhang (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/PMC13271059.txt.
Description
Longhui Han is lead author of a 2026 review on orthokeratology, often shortened to Ortho-K, a lens treatment used to slow short-sightedness in teenagers. Worn to reshape the cornea, the front of the eye, the lenses were once explained mainly by a peripheral defocus idea, meaning how light focuses at the edges of vision.
Reviewing literature from 2023 to 2025, the authors propose a three-tier network model, ranked by strength of evidence. The first tier is the direct lens effect and peripheral focus shift. The second covers nerve responses and changes in eye tissues and blood flow. The third is reshaping of the white outer coat of the eye. They also discuss wide differences between patients.
Catalog record
| CREATOR | Longhui Han, Shangkuan He, Shuting Dong, Yuying Lu, Minglian Zhang |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 52563 |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |