Characterization of blood-brain barrier L-arginine uptake using in situ brain perfusions in a female mouse model
Olivia C Milam, Cullen P Wolford, Geoffrey L Pecar, Joshua J Applegate, Maxine E Casto, Dominic J Gabriele, Austin S Nestor, Paul R Lockman · 2026
Read Characterization of blood-brain barrier L-arginine uptake using in situ brain perfusions in a female mouse model by Olivia C Milam, Cullen P Wolford, Geoffrey L Pecar, Joshua J Applegate, Maxine E Casto, Dominic J Gabriele, Austin S Nestor, Paul R Lockman (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/PMC13270607.txt.
Description
Olivia C. Milam is lead author of a 2026 journal article on how L-arginine, a building block of protein, crosses from blood into the brain in female mice. That crossing matters because L-arginine helps the brain make nitric oxide, a signal chemical, yet its transport rates in mice were not known.
Working with BALB/c mice, the team perfused, or flowed, a labeled form of L-arginine through the brain in place and varied time, dose, salt levels, and acidity. They also added blocker chemicals and related amino acids to test which carrier system moves L-arginine and how strongly other substances compete with it. The paper stays focused on that measurement work.
Catalog record
| CREATOR | Olivia C Milam, Cullen P Wolford, Geoffrey L Pecar, Joshua J Applegate, Maxine E Casto, Dominic J Gabriele, Austin S Nestor, Paul R Lockman |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 42809 |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |