Nanobioconjugate Trispecific Antibody Augments Antitumor Immunity of Triple Negative Breast Cancer
Qing Chang, Linlin Liu · 2026
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Description
Qing Chang and Linlin Liu engineer in 2026 a three-headed antibody particle aimed at triple-negative breast cancer, the subtype with the bleakest outlook and fewest drug options. Their construct grabs three targets at once: one on T cells to engage them, one that boosts T cell attack, and one enriched on the tumor. Tests in dishes and in mice carrying the aggressive 4T1 tumor model measured binding, killing, and safety.
The antibody physically linked tumor cells with T cells and sharpened the attack. Treated tumors filled with more killer T cells, including memory types that guard against return, and T cells multiplied in tumor and spleen. No obvious whole-body toxicity appeared. The authors present the trispecific design as a promising immune strategy for this hard cancer.
Catalog record
| CREATOR | Qing Chang, Linlin Liu |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 40 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |