Identification of chondroitin polymerizing factor as a biomarker for predicting immunotherapy response in breast cancer: a bioinformatics analysis of tumor microenvironment
Zimeng He, Yunsheng Xu, Chunyan Wu · 2026
Read Identification of chondroitin polymerizing factor as a biomarker for predicting immunotherapy response in breast cancer: a bioinformatics analysis of tumor microenvironment by Zimeng He, Yunsheng Xu, Chunyan Wu (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13270265.txt.
Description
Zimeng He, Yunsheng Xu, and Chunyan Wu search in 2026 public breast cancer data for a marker that predicts who benefits from immune checkpoint therapy. Many patients gain nothing lasting from these drugs, and the tumor's surrounding ecosystem helps decide the outcome. Using gene activity profiles, the team sorted tumor environments into four subtypes with differing survival and treatment response.
One molecule stood out: an enzyme that builds chondroitin chains, called CHPF. Tumors rich in it hosted fewer killer immune cells and more scar-forming and vessel cells, and its activity tracked with pathways tied to immune suppression and matrix disorder. Patients with high levels responded worse and survived less after checkpoint therapy. CHPF, the authors argue, could flag tumors unlikely to answer immunotherapy.
Catalog record
| CREATOR | Zimeng He, Yunsheng Xu, Chunyan Wu |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 42 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |