Quantitative Measurement of Extracellular Vesicle‐Sized Particles in Blood Plasma by Laser Diffraction Without an Extraction Process: A Proof‐of‐Concept Study in Atrial Fibrillation
Giichi Nitta, Kotone Tatsumi, Nurjahon Ummatalieva, Suzuka Ishikawa, Satomi Hamada, Anna Suzuki, Rina Iwasaki, Kohei Kawajiri, Ryutaro Kobayashi, Junji Yamaguchi, Ryunosuke Ohkawa, Kotaro Yoshioka, Tetsuya Nagata, Takanori Yokota, Kensuke Ihara, Tetsuo Sasano · 2026
Read Quantitative Measurement of Extracellular Vesicle‐Sized Particles in Blood Plasma by Laser Diffraction Without an Extraction Process: A Proof‐of‐Concept Study in Atrial Fibrillation by Giichi Nitta, Kotone Tatsumi, Nurjahon Ummatalieva, Suzuka Ishikawa, Satomi Hamada, Anna Suzuki, Rina Iwasaki, Kohei Kawajiri, Ryutaro Kobayashi, Junji Yamaguchi, Ryunosuke Ohkawa, Kotaro Yoshioka, Tetsuya Nagata, Takanori Yokota, Kensuke Ihara, Tetsuo Sasano (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/PMC13270222.txt.
Description
Giichi Nitta and co-authors published a proof-of-concept study in 2026 on sizing tiny cell parcels in blood plasma by laser light, without pulling them out first. The parcels, called vesicles, are shed by cells and may serve as disease markers. Pulling them out is slow work and loses many, which hurts accuracy. The test case was atrial fibrillation, a heart rhythm disorder.
Laser results matched the standard tracking method for lab-made particles and pulled-out vesicles, with steadier repeats. In raw plasma, size profiles matched those after extraction, but peak counts fell after extraction, confirming losses. Eating before sampling dirtied measures with fat particles. In fasting plasma, parcel levels were much higher in 20 patients with the rhythm disorder than in 20 controls.
Catalog record
| CREATOR | Giichi Nitta, Kotone Tatsumi, Nurjahon Ummatalieva, Suzuka Ishikawa, Satomi Hamada, Anna Suzuki, Rina Iwasaki, Kohei Kawajiri, Ryutaro Kobayashi, Junji Yamaguchi, Ryunosuke Ohkawa, Kotaro Yoshioka, Tetsuya Nagata, Takanori Yokota, Kensuke Ihara, Tetsuo Sasano |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 39653 |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |