The YTHDC1-m6A-GADD45B axis promotes chondrogenesis of hPDLSCs via suppressing senescence through p53/p21 signalling pathway
Dan Tan, Qianke Tao, Luwen Ye, Xuemei Long, Qiaonan Ye, Qilin Li, Jinlin Song, Jingang Xiao · 2026
Read The YTHDC1-m6A-GADD45B axis promotes chondrogenesis of hPDLSCs via suppressing senescence through p53/p21 signalling pathway by Dan Tan, Qianke Tao, Luwen Ye, Xuemei Long, Qiaonan Ye, Qilin Li, Jinlin Song, Jingang Xiao (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/PMC13269875.txt.
Description
Dan Tan and co-authors published a journal article in 2026 on stem cells from tooth ligaments and their potential to rebuild jaw joint cartilage. These stem cells age quickly under inflammation and low oxygen, losing their healing power. A protein that reads chemical tags on gene messages, YTHDC1, was found to guard against that aging.
Boosting YTHDC1 reduced aging signs and improved cartilage formation, while lowering it did the reverse. The protein hastens decay of a message called GADD45B, which otherwise switches on an aging pathway. Removing the tag site from that message erased the effect. In rats with jaw joint arthritis, boosted stem cells eased disease, unless the target message was restored.
Catalog record
| CREATOR | Dan Tan, Qianke Tao, Luwen Ye, Xuemei Long, Qiaonan Ye, Qilin Li, Jinlin Song, Jingang Xiao |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 51705 |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |