Use of Mendelian Randomization to Unveil Metabolic Markers in Helicobacter pylori Infection
Tung Hoang, Jeongseon Kim · 2026
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Description
Tung Hoang and Jeongseon Kim published a journal article in 2026 using genetics to find body chemicals linked to Helicobacter pylori, a stomach bacterium. Genetic variants act as natural experiments in this method. They studied antibodies against six parts of the bacterium, drawing on United Kingdom biobank data for over 10 million variants.
One hundred chemicals were positively linked to the antibodies, and 67 were negatively linked. Positive links clustered in pathways handling amino acids, the building blocks of proteins, and related cell fuels. Negative links centered on a pathway for pyrimidines, one class of DNA building blocks. The authors say the pattern shows infection leaves a body-wide metabolic footprint worth probing for its mechanisms.
Catalog record
| CREATOR | Tung Hoang, Jeongseon Kim |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 33296 |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |