Costimulation loss enhances IL-2-driven Treg generation by PI3K-STAT3 inhibition in CNS autoimmunity
Kyung-Ho Nam, Gil-Ran Kim, Yu-Rim Kim, Young Nam Kwon, Sung-Min Kim, Je-Min Choi · 2026
Read Costimulation loss enhances IL-2-driven Treg generation by PI3K-STAT3 inhibition in CNS autoimmunity by Kyung-Ho Nam, Gil-Ran Kim, Yu-Rim Kim, Young Nam Kwon, Sung-Min Kim, Je-Min Choi (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13269791.txt.
Description
Kyung-Ho Nam and co-authors present a 2026 study on a drug quirk that could help calm autoimmune attacks on the brain. Abatacept blocks the costimulation T cells need, yet it also starves the regulatory T cells that keep peace, limiting itself. The authors found the blockade rewires how the growth signal IL-2 talks inside the cell.
One branch of that signal, through STAT3, needs the very costimulation the drug removes, so it falls silent. The other branch, through STAT5, survives and, joined by stronger TGF-beta signaling, switches on the master gene of regulatory cells. The result is more peacekeepers, not fewer, and mice with a multiple sclerosis model improved. Human cells from patients showed the same synergy. Pairing the drug with IL-2 could flip its weakness into strength.
Catalog record
| CREATOR | Kyung-Ho Nam, Gil-Ran Kim, Yu-Rim Kim, Young Nam Kwon, Sung-Min Kim, Je-Min Choi |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 82 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |