HIV-1 Tat-driven Glutamate Dysregulation: Implications for Cognitive Impairment in HAND
Brenna C Duffy, Michael R Nonnemacher, Sandhya Kortagere · 2026
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Description
Brenna C Duffy, Michael R Nonnemacher, and Sandhya Kortagere published a review in 2026 on how an HIV protein called Tat may drive thinking problems in people with HIV. These problems affect 15 to 50 percent of patients, harming learning, memory, and planning. Tat is made over long periods by infected brain support cells.
The review weighs direct harm to nerve cells against indirect harm through activated support cells. Recent models show Tat switching those cells into states that disturb glutamate, a key signal chemical, by altering its receptors and transporters. Too much glutamate can overexcite and damage nerve cells. The authors argue that studying both routes can point to new treatment targets.
Catalog record
| CREATOR | Brenna C Duffy, Michael R Nonnemacher, Sandhya Kortagere |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 59189 |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |