Expression of GPR34 in microglia remains stable in human Alzheimer’s disease
Sophie Seiffer, Jonas Rotter, Jana Brendler, Albert Ricken, Zoe Detzer, Max Braune, Torsten Schöneberg, Angela Schulz, Karsten Winter, Ingo Bechmann · 2026
Read Expression of GPR34 in microglia remains stable in human Alzheimer’s disease by Sophie Seiffer, Jonas Rotter, Jana Brendler, Albert Ricken, Zoe Detzer, Max Braune, Torsten Schöneberg, Angela Schulz, Karsten Winter, Ingo Bechmann (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/PMC13269318.txt.
Description
Sophie Seiffer and co-authors published a journal article in 2026 on a sensor protein called GPR34 in microglia, the brain's resident immune cells, in Alzheimer's disease. Loss of this sensor was known to weaken the cells' cleanup work. Whether its levels change as the disease advances was unclear.
The team counted 187,670 microglia in tissue from older donors and also mined data from 236,002 cells. Cell numbers and shapes were largely preserved, whatever the nearby burden of amyloid plaques or tau tangles, the two hallmark deposits. GPR34 levels varied widely from cell to cell and by brain region. They did not track steadily with disease stage. The authors call its control highly dependent on local context.
Catalog record
| CREATOR | Sophie Seiffer, Jonas Rotter, Jana Brendler, Albert Ricken, Zoe Detzer, Max Braune, Torsten Schöneberg, Angela Schulz, Karsten Winter, Ingo Bechmann |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 85162 |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |