Variability and longitudinal dynamics of donor-derived cell-free DNA in kidney and liver recipients: a comparison of absolute and relative quantities in plasma and urine
Fanny Sandberg, Nicholas Kueng, Vanessa Banz, Annalisa Berzigotti, Daniel Sidler, Carlo R. Largiadèr, Ursula Amstutz · 2026
Read Variability and longitudinal dynamics of donor-derived cell-free DNA in kidney and liver recipients: a comparison of absolute and relative quantities in plasma and urine by Fanny Sandberg, Nicholas Kueng, Vanessa Banz, Annalisa Berzigotti, Daniel Sidler, Carlo R. Largiadèr, Ursula Amstutz (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13269088.txt.
Description
Fanny Sandberg and co-authors track in 2026 how donor DNA fragments in blood and urine fluctuate in kidney and liver transplant patients over the first two years. Such fragments signal graft injury, yet natural variation can muddy fixed cutoff values. Samples came from regular follow-up visits, and a genetic mismatch method measured both the absolute amount and the share of donor DNA.
In stable kidney patients, variation between and within people was similar for both measures. In liver patients, most variation happened within each person over time rather than between people. Urine donor DNA in kidney patients also differed by sex for the fractional measure. The authors advise reading each patient's own trend alongside cutoffs, and weighing the absolute measure more in liver and urine testing.
Catalog record
| CREATOR | Fanny Sandberg, Nicholas Kueng, Vanessa Banz, Annalisa Berzigotti, Daniel Sidler, Carlo R. Largiadèr, Ursula Amstutz |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 39 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |