Rethinking neonatal Escherichia coli sepsis: the overlooked role of maternally transferred immunity
Daolin Tang, Rui Kang · 2026
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Description
Daolin Tang and Rui Kang argue in 2026 that a newborn's risk of E. coli blood infection depends heavily on antibodies received from the mother before birth. Newborn sepsis kills many infants each year, and E. coli is a leading cause, yet only a minority of exposed babies fall ill. The commentary discusses a recent Nature study that shifted attention from the baby's immature defenses to the mother's immune gift.
Antibodies against E. coli cross the placenta late in pregnancy through a specialized receptor, arming the baby to clear bacteria after birth. Babies who receive too little of that protection may fail to control early colonization. Maternal exposure history, even to friendly E. coli strains, could thus shape a newborn's first defense, opening ideas for prevention.
Catalog record
| CREATOR | Daolin Tang, Rui Kang |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 16 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |