Immunomodulation by platelet-derived DKK1: potential for controlling disease and pathology in leishmaniasis and implications for other infectious diseases
Olivia C. Ihedioha, Diane McMahon-Pratt, Alfred L. M. Bothwell · 2026
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Description
Olivia C Ihedioha, Diane McMahon-Pratt, and Alfred L M Bothwell review in 2026 how platelets, the blood cells known for clotting, can tilt immunity during leishmaniasis, a parasitic skin disease. Infected mice release a platelet protein called DKK1, which blocks a signaling pathway named Wnt. The review gathers evidence on what that release does to the immune response at infection sites.
DKK1 release encouraged clumping of white cells with platelets and drew neutrophils, macrophages, and dendritic cells into tissue. It also steered dendritic cells toward responses that help the parasite survive inside macrophages, while weakening the protective response type. Similar platelet behavior may matter in fungal and viral infections, making DKK1 a candidate target worth testing.
Catalog record
| CREATOR | Olivia C. Ihedioha, Diane McMahon-Pratt, Alfred L. M. Bothwell |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 51 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |