Proximity labeling proteomics maps radial glial ciliary proteins across the developing telencephalon
Xiaoliang Liu, Oscar T. Gutierrez, Sabyasachi Baboo, Eva Cai, Gurleen Kaur, Yazan Al-Issa, Jolene K. Diedrich, John R. Yates, Xuecai Ge · 2026
Read Proximity labeling proteomics maps radial glial ciliary proteins across the developing telencephalon by Xiaoliang Liu, Oscar T. Gutierrez, Sabyasachi Baboo, Eva Cai, Gurleen Kaur, Yazan Al-Issa, Jolene K. Diedrich, John R. Yates, Xuecai Ge (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13268694.txt.
Description
Xiaoliang Liu and co-authors present a 2026 map of the proteins inside cilia, the hair-like signposts on brain stem cells. Radial glia grow the cortex, and their cilia host key growth signals, yet the cilia's parts list was guesswork. The team tagged proteins near the cilia in living mouse embryos with a proximity label tool, then read the catch. Maps were drawn apart for the top and bottom halves of the front brain.
Ribosome parts, the cell's protein makers, turned up inside cilia, a surprise guest. Two disease-linked proteins also sat there, one shaping cell polarity and one tied to a rare syndrome. Follow-up tests showed each steers growth steps. The data set is now a shared mine for brain build studies.
Catalog record
| CREATOR | Xiaoliang Liu, Oscar T. Gutierrez, Sabyasachi Baboo, Eva Cai, Gurleen Kaur, Yazan Al-Issa, Jolene K. Diedrich, John R. Yates, Xuecai Ge |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 66 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |