An investigation into the use of Caenorhabditis elegans as a model organism for nerve agent exposure research
Johanna Haszczyn, A. Christopher Green, Lindy Holden-Dye, Vincent O'Connor, James Kearn · 2026
Read An investigation into the use of Caenorhabditis elegans as a model organism for nerve agent exposure research by Johanna Haszczyn, A. Christopher Green, Lindy Holden-Dye, Vincent O'Connor, James Kearn (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13268407.txt.
Description
Nerve agents exert their toxicological effects via inhibition of acetylcholinesterase (AChE). This inhibition results in excessive cholinergic signalling, which can result in fatality through cessation of breathing. Current therapies for nerve agent poisoning antagonise the overstimulation of muscarinic acetylcholine receptors and use benzodiazepines to enhance GABAergic inhibition as a counter to increased excitability in the central nervous system.
Catalog record
| CREATOR | Johanna Haszczyn, A. Christopher Green, Lindy Holden-Dye, Vincent O'Connor, James Kearn |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 54 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |