Constitutional BRCA1 Promoter Methylation in Patients With Ovarian Cancer: Results of the Observational AGO-TR1 Study
Mohamad Kayali, Eric Hahnen, Alexander Burges, Alexander Reuss, Julia Caro-Valenzuela, Nikolaus de Gregorio, Florian Heitz, Sandra Schmidt, Frederik Marmé, Felix Hilpert, Pauline Wimberger, Stefan Kommoss, Katharina Prieske, Christoph Engel, Paul Buderath, Dimo Dietrich, Rita Schmutzler, Jalid Sehouli, Kerstin Rhiem, Philipp Harter, Jan Hauke · 2026
Read Constitutional BRCA1 Promoter Methylation in Patients With Ovarian Cancer: Results of the Observational AGO-TR1 Study by Mohamad Kayali, Eric Hahnen, Alexander Burges, Alexander Reuss, Julia Caro-Valenzuela, Nikolaus de Gregorio, Florian Heitz, Sandra Schmidt, Frederik Marmé, Felix Hilpert, Pauline Wimberger, Stefan Kommoss, Katharina Prieske, Christoph Engel, Paul Buderath, Dimo Dietrich, Rita Schmutzler, Jalid Sehouli, Kerstin Rhiem, Philipp Harter, Jan Hauke (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/PMC13268109.txt.
Description
Mohamad Kayali and a large team report 2026 results from the AGO-TR1 study on a chemical silencing mark in ovarian cancer. The mark sits on the BRCA1 gene, a gene whose inherited faults raise cancer risk. Unlike a mutation, this mark is a methylation tag present from early development in normal tissues, including blood. The team measured it in 473 women with ovarian cancer and 476 controls.
The mark appeared in about 9 percent of patients and about 5 percent of controls. At high levels, the link to cancer grew much stronger. Women carrying the mark were diagnosed younger, at a median of 54 against 60. Half of the tumors showing the mark traced back to this body-wide form. The authors call it a robust marker of personal ovarian cancer risk.
Catalog record
| CREATOR | Mohamad Kayali, Eric Hahnen, Alexander Burges, Alexander Reuss, Julia Caro-Valenzuela, Nikolaus de Gregorio, Florian Heitz, Sandra Schmidt, Frederik Marmé, Felix Hilpert, Pauline Wimberger, Stefan Kommoss, Katharina Prieske, Christoph Engel, Paul Buderath, Dimo Dietrich, Rita Schmutzler, Jalid Sehouli, Kerstin Rhiem, Philipp Harter, Jan Hauke |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 32330 |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |