Therapeutic Potential of Naive Hair Follicle Stem Cells in Alzheimer’s Disease: A Comprehensive Evaluation of Neuroprotection and Neurogenesis
Lina Liu, Dan Yang, Jin Fu · 2026
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Description
Lina Liu, Dan Yang, and Jin Fu present a 2026 rat study of hair follicle stem cells for Alzheimer's disease. Current Alzheimer's drugs ease symptoms but do not rebuild the brain. Stem cells from hair roots are easy to gather and raise no ethical concerns. The team tested plain, unmodified cells in rats given a toxic protein fragment to mimic the disease.
Two weeks after the disease model was set, cells were placed into the hippocampus, a memory center. Treated rats later showed higher levels of two proteins that mark healthy synapses, the links between brain cells. The grafts also spurred new neuron growth in the region. Immune cells in the brain, which overreact in Alzheimer's, calmed down. Inflammation signals shifted toward a quieter profile. The authors call the cells promising for future therapy.
Catalog record
| CREATOR | Lina Liu, Dan Yang, Jin Fu |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 55119 |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |