Early Risk Factors and Clinical Characteristics of Pediatric Hemophagocytic Lymphohistiocytosis: A Single-Center Retrospective Study
Ziming Wang, Zhining Geng, Yongli Xuan, Xinhui Luo · 2026
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Description
Ziming Wang and colleagues wrote a 2026 study of early warning signs for a dangerous inflammatory syndrome in children. The syndrome, called HLH, is an overreaction of the immune system that can move fast and kill. The team reviewed 205 children suspected of the syndrome at a children's hospital in Xinjiang between 2021 and 2026.
Of the children, 56, about 27 percent, were confirmed to have HLH. A statistical method picked five early signals tied to the diagnosis: how long fever lasted, and blood levels of ferritin, triglycerides, fibrinogen, and D-dimer. Combined, the five gave fair sorting power between children with and without the syndrome. Checks showed the model was well calibrated. The authors offer the signals as a quick early screen for doctors facing a sick, feverish child.
Catalog record
| CREATOR | Ziming Wang, Zhining Geng, Yongli Xuan, Xinhui Luo |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 30558 |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |