Ca2+-driven self-amplified nanoplatform targeting ER-mitochondrial calcium crosstalk for synergistic apoptosis induction and tumor immune microenvironment remodeling
Yucui Ding, Xinyu Liu, Jianlong Fu, Jianyue Xue, Xueni Fan, Yundong Wang, Xinrui Li, Sirui Liu, Yunchao Yang, Xiaopeng Xu, Gangqiang Yang, Hongbo Wang, Peng Zhang · 2026
Read Ca2+-driven self-amplified nanoplatform targeting ER-mitochondrial calcium crosstalk for synergistic apoptosis induction and tumor immune microenvironment remodeling by Yucui Ding, Xinyu Liu, Jianlong Fu, Jianyue Xue, Xueni Fan, Yundong Wang, Xinrui Li, Sirui Liu, Yunchao Yang, Xiaopeng Xu, Gangqiang Yang, Hongbo Wang, Peng Zhang (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/PMC13267731.txt.
Description
Yucui Ding and colleagues report a 2026 study of a nano-sized drug carrier built to overwhelm breast cancer cells with calcium. Drug resistance and spread limit chemotherapy for breast cancer. The carrier wraps a plant compound, oridonin, in a manganese-based mineral sheet inside a fat shell aimed at tumors. Once inside a cell, it sets off a self-feeding loop of stress.
Stress in the cell's protein workshop forces calcium into its power plants, which then fail and burst out damaging oxygen chemicals. Manganese adds more of those chemicals and wakes an immune alarm pathway. Immune cells inside the tumor shifted to an attacking mode, and killer T cells moved in. In mice, the carrier strongly shrank tumors with no clear whole-body harm.
Catalog record
| CREATOR | Yucui Ding, Xinyu Liu, Jianlong Fu, Jianyue Xue, Xueni Fan, Yundong Wang, Xinrui Li, Sirui Liu, Yunchao Yang, Xiaopeng Xu, Gangqiang Yang, Hongbo Wang, Peng Zhang |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 54583 |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |