A multidimensional biomarker model of vitality and its associations with intrinsic capacity and frailty
J Chew, JQ Chia, JP Lim, A Yeo, CN Tan, SP Chan, CL Lim, WS Lim · 2026
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Description
J Chew and co-authors test in 2026 whether vitality in older age is better captured by a panel of body biomarkers than by nutrition scores alone. The World Health Organization treats vitality as the reserve built from muscle, metabolic, and stress-response systems. Their study analyzed 300 independent community-dwelling older adults, most of them women in their late sixties.
Statistical modeling found the biomarkers naturally grouped into those three domains rather than one single score. Muscle-related vitality linked to overall capacity and thinking ability, while metabolic and inflammation profiles linked to movement capacity and lower frailty. A short nutrition questionnaire related only to frailty. The authors argue that healthy aging programs should track vitality as a layered physical profile.
Catalog record
| CREATOR | J Chew, JQ Chia, JP Lim, A Yeo, CN Tan, SP Chan, CL Lim, WS Lim |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 42 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |