Recent advances in copper-catalyzed direct hydroamination of alkenes with (hetero)aromatic amines
Hyejeong Lee, Yunmi Lee · 2026
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Description
Hyejeong Lee and Yunmi Lee wrote a 2026 review of copper-based methods for joining nitrogen groups to carbon chains. Aromatic amines, ring-shaped nitrogen compounds, appear in many drugs and advanced materials. Adding an N-H bond across a double bond is a clean way to build them, but these nitrogen partners react weakly and bind metals in tricky ways.
Copper catalysts have recently opened several routes around these problems. The review sorts them into paths that use copper-nitrogen attack, acid-like activation of the chain, and radical steps. Each path gives different control over where the nitrogen lands and which mirror form results. The authors map what governs that control, aiming to guide chemists who design new reactions.
Catalog record
| CREATOR | Hyejeong Lee, Yunmi Lee |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 49373 |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |