Integrated proteomic and metabolomic profiling reveals sex‐stratified biomarkers predicting chronicity in paediatric primary immune thrombocytopenia
Yuanyuan Xue, Rongrong Zhang, Dongmei Liang, Yupeng Xu, Zhaofang Tian, Xiaohong Dai, Wei Xu, Qingqing Cao, Haiyan Zhu, Yun Wang, Yufang Yuan · 2026
Read Integrated proteomic and metabolomic profiling reveals sex‐stratified biomarkers predicting chronicity in paediatric primary immune thrombocytopenia by Yuanyuan Xue, Rongrong Zhang, Dongmei Liang, Yupeng Xu, Zhaofang Tian, Xiaohong Dai, Wei Xu, Qingqing Cao, Haiyan Zhu, Yun Wang, Yufang Yuan (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13267447.txt.
Description
Yuanyuan Xue and co-authors hunt, separately in boys and girls, for blood markers that foretell which children with immune thrombocytopenia will turn chronic. In this disease the immune system destroys platelets, and most children recover, but some do not. Plasma from 67 newly diagnosed children and 40 healthy controls was banked. After at least a year of follow-up, each child was classed as chronic or not.
Protein and metabolite profiling was done on samples from each sex and outcome subgroup. In boys, two markers stood out: the adhesion molecule ICAM-1 and biopterin. In girls, the standouts were a smooth muscle actin and an acetylated amino acid. Swapping marker sets across sexes gave poor prediction: the road to chronic disease seems to differ by sex. Prognosis tools may need building twice, once per sex.
Catalog record
| CREATOR | Yuanyuan Xue, Rongrong Zhang, Dongmei Liang, Yupeng Xu, Zhaofang Tian, Xiaohong Dai, Wei Xu, Qingqing Cao, Haiyan Zhu, Yun Wang, Yufang Yuan |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 31 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |