Co-designing primary and secondary outcome measures for an international phase 3 trial of surgical de-escalation in vulvar cancer through a consumer workshop
Lauren Angel, Monika Janda, Andrew Martin, Brianna Armstrong, Merran Williams, Nicola Du Thaler, Emma Wild, Mary Li, Andreas Obermair · 2026
Read Co-designing primary and secondary outcome measures for an international phase 3 trial of surgical de-escalation in vulvar cancer through a consumer workshop by Lauren Angel, Monika Janda, Andrew Martin, Brianna Armstrong, Merran Williams, Nicola Du Thaler, Emma Wild, Mary Li, Andreas Obermair (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/PMC13267351.txt.
Description
Lauren Angel and colleagues describe a 2026 workshop that let patients help design a vulvar cancer trial. Standard care removes lymph nodes in the groin, which can cause lasting swelling and harm. The planned ANVU trial, across several countries, will test whether ultrasound checks can safely replace that surgery for some women.
Patients with lived experience of the disease joined the research team for a structured session. Short-term, they prized full cancer removal and accepted some side effects. Later, quality of life, fear of the cancer returning, and avoiding chronic swelling mattered most. These views set the trial's main outcome, survival after node spread at 30 months, and added patient-centered measures such as return to daily life.
Catalog record
| CREATOR | Lauren Angel, Monika Janda, Andrew Martin, Brianna Armstrong, Merran Williams, Nicola Du Thaler, Emma Wild, Mary Li, Andreas Obermair |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 24220 |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |