Tau profiling of brain extracellular vesicles reveals PHF6 peptide as core for pathological tau seeding in Alzheimer's disease
Marie Oosterlynck, Laura Fichter, Elodie Leroux, Sabiha Eddarkaoui, Thomas Bouillet, Camille Lefebvre, Marine Nguyen, Claude-Alain Maurage, Bertrand Accart, Elian Dupré, Isabelle Landrieu, Clément Danis, Sylvain Lehmann, Jérôme Vialaret, Luc Buée, Christophe Hirtz, Morvane Colin · 2026
Read Tau profiling of brain extracellular vesicles reveals PHF6 peptide as core for pathological tau seeding in Alzheimer's disease by Marie Oosterlynck, Laura Fichter, Elodie Leroux, Sabiha Eddarkaoui, Thomas Bouillet, Camille Lefebvre, Marine Nguyen, Claude-Alain Maurage, Bertrand Accart, Elian Dupré, Isabelle Landrieu, Clément Danis, Sylvain Lehmann, Jérôme Vialaret, Luc Buée, Christophe Hirtz, Morvane Colin (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/PMC13267276.txt.
Description
Marie Oosterlynck and a large team report a 2026 study of tiny particles that may spread tau damage in the brain. In Alzheimer's disease, the tau protein clumps and seems to pass from cell to cell. Small sacs released by brain cells, called extracellular vesicles, carry tau seeds, but which tau forms drive the spread was unknown.
The team took these sacs from frozen brain tissue of patients with three tau diseases and from healthy controls. Protein profiling showed that each disease left a distinct tau pattern in the sacs. Alzheimer's sacs were rich in tau pieces from one key region. A short piece named PHF6 did most of the seeding work. The authors name PHF6 as a possible drug target.
Catalog record
| CREATOR | Marie Oosterlynck, Laura Fichter, Elodie Leroux, Sabiha Eddarkaoui, Thomas Bouillet, Camille Lefebvre, Marine Nguyen, Claude-Alain Maurage, Bertrand Accart, Elian Dupré, Isabelle Landrieu, Clément Danis, Sylvain Lehmann, Jérôme Vialaret, Luc Buée, Christophe Hirtz, Morvane Colin |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 61377 |
| LICENSE | https://creativecommons.org/publicdomain/zero/1.0 |
| RIGHTS | CC0 |
| SOURCE | Europe PMC |