Mechanistic and therapeutic insights into class A GPCR dimers in neuropsychiatric disorders
Zhaojing Wang, Linlin Wang, Shicheng Zhang · 2026
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Description
Zhaojing Wang, Linlin Wang, and Shicheng Zhang review in 2026 how pairs of class A G protein-coupled receptors can work as dimers in mental disorders. These receptors form the largest family of drug targets, and most sit in the brain, shaping mood, thought, and behavior. When two receptors pair, their signaling can differ sharply from either one acting alone.
The review gathers evidence on which dimers appear in neuropsychiatric conditions and what they do to cells. It then analyzes the known structures of receptor pairs to explain how they assemble and switch on. Current attempts to design drugs that hit only a specific pair are assessed, offering a framework for more precise mental health medicines.
Catalog record
| CREATOR | Zhaojing Wang, Linlin Wang, Shicheng Zhang |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 76 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |