Oral self-assembly nanoemulsion drives in vivo hepatic stellate cell-targeting drug delivery in liver fibrosis
Xinjing Shen, Jie Deng, Aijiao Jiang, Qianqi Cai, Deyong Tian, Linlin Zhao, Jing Ye, Lie Zhang, Yucheng Xiang, Quan Zhang · 2026
Read Oral self-assembly nanoemulsion drives in vivo hepatic stellate cell-targeting drug delivery in liver fibrosis by Xinjing Shen, Jie Deng, Aijiao Jiang, Qianqi Cai, Deyong Tian, Linlin Zhao, Jing Ye, Lie Zhang, Yucheng Xiang, Quan Zhang (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/PMC13267024.txt.
Description
Xinjing Shen and colleagues report a 2026 study of a drinkable drug carrier aimed at scarred liver tissue. Liver fibrosis builds up when star-shaped liver cells switch on and lay down excess matrix. The team loaded a plant compound called morin into tiny oil droplets marked with vitamin A, which those cells tend to take up.
In rats with chemically induced liver scarring, the oral carrier crossed the gut wall intact and reached the liver through the lymph route. Treated rats showed less scarring, less of a scar marker, and lower levels of a key scar-driving signal. Liver function also improved. The authors offer the system as a long-term oral option for fibrosis care.
Catalog record
| CREATOR | Xinjing Shen, Jie Deng, Aijiao Jiang, Qianqi Cai, Deyong Tian, Linlin Zhao, Jing Ye, Lie Zhang, Yucheng Xiang, Quan Zhang |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 62613 |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |