Immune research progress of Slit2-Robo signaling axis in chronic obstructive pulmonary disease: a narrative review
Weiwei An, Dejin Liang · 2026
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Description
Weiwei An and Dejin Liang review a guidance signal's role in smoking damaged lungs. Chronic obstructive pulmonary disease kills millions, and smoke is its chief cause. The Slit2 Robo axis steers cell movement and calms or stirs immune traffic. New work ties it to smoke driven lung inflammation and tissue reshaping.
The axis shapes how neutrophils, macrophages, and lymphocytes gather and act. It also talks with the pathways that brew inflammatory signals. Beyond inflammation, it plays a double role in repair, touching lining integrity, blood vessel growth, and scarring. Most proof still comes from early stage studies. The authors see a promising drug target, pending stronger evidence.
Catalog record
| CREATOR | Weiwei An, Dejin Liang |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 36 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |