Neural mechanisms of cough: insights from multimodal magnetic resonance imaging—a narrative review
Xinyi Liu, Yijing Wang, Chen Chen, Chunwei Wu, Bo Zhang, Zhandong Liu, Ying Xie, Peijun Gui · 2026
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Description
Xinyi Liu and co-authors review in 2026 what brain imaging reveals about how cough is controlled, beyond the basic reflex in the brainstem. Chronic cough and an oversensitive cough reflex involve changes in both airway nerves and higher brain centers. Their review searched studies using structural, functional, and diffusion magnetic resonance imaging up to early 2026.
Together, those scans outline a network whose hubs include the prefrontal cortex, the anterior cingulate cortex, and a brainstem relay nucleus. The review also describes how central sensitization may keep stubborn cough going. Imaging markers could guide drug treatment or gentle brain stimulation for patients whose cough resists standard care, moving treatment toward a more personal fit.
Catalog record
| CREATOR | Xinyi Liu, Yijing Wang, Chen Chen, Chunwei Wu, Bo Zhang, Zhandong Liu, Ying Xie, Peijun Gui |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 38 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |