From contraindication to consideration: the role of esophagectomy in stage IV esophageal adenocarcinoma
Agustina A Pontecorvo, Enrique F Elli · 2026
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Description
Agustina A Pontecorvo and Enrique F Elli discuss in 2026 whether removing the esophagus can help selected patients whose esophageal adenocarcinoma has already spread. Surgery for metastatic disease was long ruled out, but stronger drug treatments have reopened the question. They comment on a study of stage IV patients who had surgery after long courses of systemic therapy.
Matched comparisons showed better survival for operated patients with distant spread than for similar patients managed without surgery. Results were best at experienced centers working in close multidisciplinary teams. Oddly, one stage group fared worse than the metastatic group, a pattern the authors link to hidden spread missed by scans. They frame surgery as targeted disease control for carefully chosen patients.
Catalog record
| CREATOR | Agustina A Pontecorvo, Enrique F Elli |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 8 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |