AHNAK promotes oxidative stress and inflammatory responses in chronic obstructive pulmonary disease by activating the Notch pathway
Chunhui Zhang, Yu Liu · 2026
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Description
Chunhui Zhang and Yu Liu explore in 2026 whether a large scaffold protein called AHNAK helps drive chronic obstructive pulmonary disease. The protein was predicted to be plentiful in this lung disease, but its role was unclear. They studied human blood samples, lung cells exposed to cigarette smoke extract, and mice exposed to smoke plus a bacterial component.
AHNAK levels were high in patients and in the smoke-treated cells. Turning the protein down eased oxidative stress and inflammation, and it lessened lung injury in mice. The benefit ran through the Notch signaling pathway, since reactivating that pathway undid the protection. Blocking AHNAK may offer a fresh treatment direction for a disease that current drugs only slow.
Catalog record
| CREATOR | Chunhui Zhang, Yu Liu |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 30 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |