Intrapleural fibrinolytic therapy for pleural infection: a multicentre real-world comparison of dosing regimens
Glenn Khai Wern Yong, Jonathan Jia Jun Wong, Xiaoe Zhang, Si Ling Young, Brian Lee Wei Chua, Qiao Li Tan, Imran Bin Mohamed Noor, Charlene Jin Yee Liew, Mindy Chu Ming Choong, Wui Mei Chew, Ken Junyang Goh · 2026
Read Intrapleural fibrinolytic therapy for pleural infection: a multicentre real-world comparison of dosing regimens by Glenn Khai Wern Yong, Jonathan Jia Jun Wong, Xiaoe Zhang, Si Ling Young, Brian Lee Wei Chua, Qiao Li Tan, Imran Bin Mohamed Noor, Charlene Jin Yee Liew, Mindy Chu Ming Choong, Wui Mei Chew, Ken Junyang Goh (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13266816.txt.
Description
Glenn Khai Wern Yong and co-authors compare in 2026 dosing schedules for drugs delivered into infected chest fluid at three Singapore hospitals. The treatment pairs a clot-dissolving drug with one that cuts DNA, helping thick infected fluid drain without surgery. Most of the 266 patients received twice-daily doses, while a smaller group received once-daily doses.
Overall success topped eight in ten patients, with no clear difference between once-daily and twice-daily schedules. Lower-than-standard doses of the clot-dissolving drug also performed similarly, with no extra bleeding. Starting treatment earlier linked to better success. The authors call for prospective trials to settle the best schedule, especially for Asian patients.
Catalog record
| CREATOR | Glenn Khai Wern Yong, Jonathan Jia Jun Wong, Xiaoe Zhang, Si Ling Young, Brian Lee Wei Chua, Qiao Li Tan, Imran Bin Mohamed Noor, Charlene Jin Yee Liew, Mindy Chu Ming Choong, Wui Mei Chew, Ken Junyang Goh |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 39 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |