In Vivo Imaging of a Photoactivatable Platinum Prodrug by Metal-Centered Radiolabeling
George Firth, Jana Kim, Huayun Shi, Kavitha Sunassee, Oene Zwaagstra, Karlijn van der Schilden, Philip J. Blower, Peter J. Sadler, Cinzia Imberti · 2026
Read In Vivo Imaging of a Photoactivatable Platinum Prodrug by Metal-Centered Radiolabeling by George Firth, Jana Kim, Huayun Shi, Kavitha Sunassee, Oene Zwaagstra, Karlijn van der Schilden, Philip J. Blower, Peter J. Sadler, Cinzia Imberti (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13266692.txt.
Description
George Firth and colleagues image a light-activated platinum drug in living mice using a radioactive version of its own metal, published in 2026. Such prodrugs need light timing matched to tumour arrival, yet their body fate was usually guessed from altered analogues. Metal-centred labelling preserves the true drug's identity and light reactivity.
Whole-body scans showed rapid kidney clearance. Unexpected, persistent build-up appeared in the bladder wall. That behaviour was absent for cisplatin and for modified analogues. Direct tracking thus reveals biology that indirect labels miss. The method can guide irradiation timing for this drug class.
Catalog record
| CREATOR | George Firth, Jana Kim, Huayun Shi, Kavitha Sunassee, Oene Zwaagstra, Karlijn van der Schilden, Philip J. Blower, Peter J. Sadler, Cinzia Imberti |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 13 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |