Pressurized intrathoracic aerosol chemotherapy (PITAC) for malignant pleural mesothelioma—ex vivo evaluation of optimal treatment conditions and comparison with hyperthermic intrathoracic chemotherapy (HITOC)
Katharina Flöthmann, Norman Zinne, Peter Braubach, Alina Meininger, Imke Becker, Nicole Ernst, Arjang Ruhparwar, Hayan Merhej, Patrick Zardo · 2026
Read Pressurized intrathoracic aerosol chemotherapy (PITAC) for malignant pleural mesothelioma—ex vivo evaluation of optimal treatment conditions and comparison with hyperthermic intrathoracic chemotherapy (HITOC) by Katharina Flöthmann, Norman Zinne, Peter Braubach, Alina Meininger, Imke Becker, Nicole Ernst, Arjang Ruhparwar, Hayan Merhej, Patrick Zardo (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13266655.txt.
Description
Katharina Flöthmann and the team test pressurised aerosol chemotherapy inside the chest for mesothelioma using tissue outside the body (2026). The rare cancer has poor outlook and few options. Aerosol delivery of cisplatin was compared with heated liquid chemotherapy. Temperature, drug strength, and tissue barrier were varied systematically.
Warmer conditions, stronger drug, and removing the pleural lining each deepened penetration. Under clinically relevant settings, aerosol treatment penetrated tissue better than the heated liquid method. The preclinical results suggest the aerosol approach may be a viable alternative. Further medical study is warranted before patient use.
Catalog record
| CREATOR | Katharina Flöthmann, Norman Zinne, Peter Braubach, Alina Meininger, Imke Becker, Nicole Ernst, Arjang Ruhparwar, Hayan Merhej, Patrick Zardo |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 33 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |