Design, Synthesis, and Structure–Activity Optimization of Marine-Inspired Macrolactones as Nanomolar Anticancer Agents
Shan Qian, Haibo Qiu, Phillip R. Sanchez, Sarah A. Head, Ruth Hartke, Jun O. Liu, Wei Zheng, Zhendong Jin · 2026
Read Design, Synthesis, and Structure–Activity Optimization of Marine-Inspired Macrolactones as Nanomolar Anticancer Agents by Shan Qian, Haibo Qiu, Phillip R. Sanchez, Sarah A. Head, Ruth Hartke, Jun O. Liu, Wei Zheng, Zhendong Jin (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13266650.txt.
Description
Shan Qian and co-authors craft sea-inspired ring compounds that kill cancer cells at very low doses, in a study from two thousand twenty-six. The lead came from a trimmed copy of a sea natural product with strong cancer action. Design, build steps, and trait tuning started from that lead, named ZJ-101.
New versions beat the lead by thirty to eighty times in cell tests. Most top values sat in the single-digit nanomolar range, a mark of high potency. The build route joins parts in a convergent way that eases variant making. Fine trait detail stays in the full text. Readers in drug design get a potent ring family ready for deeper checks.
Catalog record
| CREATOR | Shan Qian, Haibo Qiu, Phillip R. Sanchez, Sarah A. Head, Ruth Hartke, Jun O. Liu, Wei Zheng, Zhendong Jin |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 14 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |