Beyond Neddylation Inhibition: X‑ray Structures Reveal Carbonic Anhydrase Isoform Selectivity of Pevonedistat
Chiara Baroni, Marta Ferraroni, Claudiu T. Supuran, Andrea Angeli · 2026
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Description
Chiara Baroni and colleagues report crystal structures revealing an unexpected second target of an anticancer drug, published in 2026. Pevonedistat blocks a protein-tagging enzyme and is in clinical testing. X-ray structures were solved with three forms of carbonic anhydrase, enzymes that manage acidity. The drug inhibited two tumour-linked forms selectively.
Those two forms thrive in low-oxygen tumour environments. Binding to red blood cell enzymes explains the drug's known pooling in whole blood. Acidity control may therefore contribute to its anticancer activity alongside tagging blockade. The dual profile offers a design lead for future drugs exploiting both actions.
Catalog record
| CREATOR | Chiara Baroni, Marta Ferraroni, Claudiu T. Supuran, Andrea Angeli |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 13 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |