Hippo pathway activation drives fibrogenic remodelling in influenza A virus-infected lung fibroblasts
Yasmina Reisser, Elaine Winkler, Julia Hoffmann, Nilima Dinesh Kumar, Antje Häder, Susanne M. Lang, Bettina Löffler, Stefanie Deinhardt-Emmer · 2026
Read Hippo pathway activation drives fibrogenic remodelling in influenza A virus-infected lung fibroblasts by Yasmina Reisser, Elaine Winkler, Julia Hoffmann, Nilima Dinesh Kumar, Antje Häder, Susanne M. Lang, Bettina Löffler, Stefanie Deinhardt-Emmer (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13266427.txt.
Description
Yasmina Reisser and co-authors trace how flu infection pushes lung fibroblasts toward scar building, in a study from 2026. Lung fibrosis stiffens the lungs and often kills, and its triggers are murky. Fibroblasts and macrophages are the main actors in the bad remodeling that follows injury.
The team infected macrophage-like cells with influenza A and fed their output to fibroblasts, and also infected the fibroblasts directly. Infected macrophages released signals that switched fibroblasts into a fibrotic mode from a distance. Direct infection worked another route: it stirred the Hippo signaling pathway, raising markers like CTGF, fibronectin, and collagen I. The authors say this two-pronged crosstalk may explain why aging lungs scar after viral hits.
Catalog record
| CREATOR | Yasmina Reisser, Elaine Winkler, Julia Hoffmann, Nilima Dinesh Kumar, Antje Häder, Susanne M. Lang, Bettina Löffler, Stefanie Deinhardt-Emmer |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 33 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |