Gray zone possibility in repeat Bethesda III cytology: a retrospective cohort study of malignancy and multifocality in thyroid nodules
Nevin Sakoglu, Ferhat Ozden · 2026
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Description
Nevin Sakoglu and Ferhat Ozden study uncertain thyroid cytology results and true cancer risk, in a 2026 retrospective cohort. Bethesda category three covers atypia of unknown significance. Three hundred patients who had total thyroid removal were reviewed. Imaging classification and cytology were compared for prediction.
Half the cohort fell into the uncertain category on review. Tissue results confirmed cancer in about a third of all patients. More than a quarter of cancers were multifocal, and a quarter were microcarcinomas. Most cancers arose in samples with cellular atypia. The authors argue the category understates risk from hidden small or multiple cancers.
Catalog record
| CREATOR | Nevin Sakoglu, Ferhat Ozden |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 35 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |