A comparison of the safety of oral labetalol versus nifedipine to manage hypertension in pregnancy in Australia: a target trial emulation
Jessica A. Atkinson, Anthea C. Lindquist, Stephen Tong, Richard J. Hiscock, Anna Forsythe, Hannah G. Gordon, Susan P. Walker, Su Jen Chua, Catherine Cluver, Jenny Myers, Roxanne M. Hastie · 2026
Read A comparison of the safety of oral labetalol versus nifedipine to manage hypertension in pregnancy in Australia: a target trial emulation by Jessica A. Atkinson, Anthea C. Lindquist, Stephen Tong, Richard J. Hiscock, Anna Forsythe, Hannah G. Gordon, Susan P. Walker, Su Jen Chua, Catherine Cluver, Jenny Myers, Roxanne M. Hastie (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13266230.txt.
Description
Jessica A Atkinson and the team compare two blood pressure drugs in pregnancy using Australian linked data (2026). Labetalol and nifedipine are both common oral choices, with unclear comparative safety. The target trial emulation covered Victorian pregnancies from 2009 to 2020. Results ran from first prescription to four weeks after birth.
A total of 7,416 pregnancies qualified, and most got labetalol first. After adjustment, nifedipine linked to higher risk of the combined maternal harm outcome. Event rates differed by several percentage points between groups. Neonatal results formed the second primary measure. The design mimics a trial using routine data.
Catalog record
| CREATOR | Jessica A. Atkinson, Anthea C. Lindquist, Stephen Tong, Richard J. Hiscock, Anna Forsythe, Hannah G. Gordon, Susan P. Walker, Su Jen Chua, Catherine Cluver, Jenny Myers, Roxanne M. Hastie |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 70 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |