CGM-derived postprandial glucose with IcoSema versus other insulin regimens: a post hoc analysis of COMBINE 1 and 3
Christophe De Block, Malik Benamar, Ariel Fu, Raluca Maltesen, Francesco Giorgino · 2026
Read CGM-derived postprandial glucose with IcoSema versus other insulin regimens: a post hoc analysis of COMBINE 1 and 3 by Christophe De Block, Malik Benamar, Ariel Fu, Raluca Maltesen, Francesco Giorgino (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13266221.txt.
Description
Christophe De Block and the team analyse meal-time glucose control for a weekly combination diabetes treatment (2026). IcoSema combines weekly insulin with semaglutide in one product. Two completed phase three trials supplied continuous glucose monitoring data. A modified algorithm detected meals from sensor traces.
Data from 1,650 people were analysed, with about two meals detected daily per person. The combination clearly improved post-meal glucose measures. Comparators were weekly insulin alone in one trial and daily multi-injection therapy in the other. Final treatment weeks provided the sensor data. Full effect details follow in the complete report.
Catalog record
| CREATOR | Christophe De Block, Malik Benamar, Ariel Fu, Raluca Maltesen, Francesco Giorgino |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 38 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |