Regulation of the endoplasmic reticulum stress sensor ATF6α through multiple oxidoreductases in the ER
Shota Wada, Kaiku Uegaki, Kazuhiro Nagata, Ryo Ushioda · 2026
Read Regulation of the endoplasmic reticulum stress sensor ATF6α through multiple oxidoreductases in the ER by Shota Wada, Kaiku Uegaki, Kazuhiro Nagata, Ryo Ushioda (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13266193.txt.
Description
Shota Wada and co-authors present 2026 cell biology findings on ATF6 alpha, a sensor that helps cells cope with stress in the endoplasmic reticulum. When unfolded proteins build up, this sensor must pair up and travel to the Golgi apparatus before it can switch on protective genes. The team asked which helper enzymes control that pairing step.
Several oxidoreductase enzymes shaped the outcome in opposite ways. ERdj5 and PDIR promoted pairing at one cysteine site, while ERp18 held it back. Pairing also stabilized the sensor and protected it from disposal inside the cell. Clarifying these controls helps explain how cells tune their stress response and avoid damage.
Catalog record
| CREATOR | Shota Wada, Kaiku Uegaki, Kazuhiro Nagata, Ryo Ushioda |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 82 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |