RNF213 isoform 2 restricts Zika virus through antiviral signaling and viral protein degradation
Xiaoyu Yang, Teng Chen, Bin Ren, Jinqiu Liu, Zhen Xu, Jingyi Wang, Yiran Shi, Lihua Liu, Lili Li, Genhong Cheng, Dongming Zhou, Qi Chen, Shulong Zu · 2026
Read RNF213 isoform 2 restricts Zika virus through antiviral signaling and viral protein degradation by Xiaoyu Yang, Teng Chen, Bin Ren, Jinqiu Liu, Zhen Xu, Jingyi Wang, Yiran Shi, Lihua Liu, Lili Li, Genhong Cheng, Dongming Zhou, Qi Chen, Shulong Zu (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13266186.txt.
Description
Xiaoyu Yang and colleagues show how a short form of a host protein restricts Zika virus, published in 2026. Related proteins are known antiviral defenders. The shorter RNF213 isoform was unexplored. Cell experiments tested its effects on viral sensing pathways and viral proteins.
The protein switched on two viral sensor pathways that raise alarms. It also sent several Zika proteins for destruction through two disposal routes. A twenty-three-amino-acid fragment taken from it reproduced the antiviral effect in cells. Viral replication fell under the fragment. The authors define a minimal active piece that could inspire antiviral design.
Catalog record
| CREATOR | Xiaoyu Yang, Teng Chen, Bin Ren, Jinqiu Liu, Zhen Xu, Jingyi Wang, Yiran Shi, Lihua Liu, Lili Li, Genhong Cheng, Dongming Zhou, Qi Chen, Shulong Zu |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 45 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |